Epipregnanolone

CAS: 128-21-2

Ref. TR-E588640

Product Information

• Name: Epipregnanolone
• Synonyms: Pregnan-20-one, 3-hydroxy-, (3ß,5ß)-, 5ß-Pregnan-20-one, 3ß-hydroxy- (6CI,8CI), (3ß,5ß)-3-Hydroxypregnan-20-one, 3-Deoxo-3ß-hydroxy-5ß-dihydroprogesterone, 3ß,5ß-Pregnanolone, 3ß-Hydroxy-5ß-pregnan-20-one, 3ß-Hydroxy-5ß-pregnane-20-one, 3ß-Hydroxy-5ß-tetrahydroprogesterone, 5ß-Pregnan-3ß-ol-20-one, 5ß-Pregnane-3ß-hydroxy-20-one, 5ß-Pregnane-3ß-ol-20-one, NSC 21450, Pregnanolone I, (3Beta,5Alpha,17Alpha)-3-Hydroxypregnan-20-One, (3Beta,5Beta)-3-Hydroxypregnan-20-One, (3Beta,5Beta,8Xi,9Xi,14Xi,17Xi)-3-Hydroxypregnan-20-One, (3β,5β)-3-Hydroxypregnan-20-one, 3-Beta-Hydroxy-5-Beta-Pregnan-20-One, 3-Deoxo-3β-hydroxy-5β-dihydroprogesterone, 3β,5β-Pregnanolone, 3β-Hydroxy-5β-pregnan-20-one, 3β-Hydroxy-5β-pregnane-20-one, 3β-Hydroxy-5β-tetrahydroprogesterone, 5β-Pregnan-20-one, 3β-hydroxy-, 5β-Pregnan-3β-ol-20-one, 5β-Pregnane-3β-hydroxy-20-one, 5β-Pregnane-3β-ol-20-one, Pregnan-20-one, 3-hydroxy-, (3β,5β)-

Description

Applications Epipregnanolone is an epimer of the hyponotic-anaesthetic agent Pregnanolone (P711300). Epipregnanolone displays anesthetic, hypnotic, and sedative properties. Epipregnanolone has been shown to reduce alcohol self-administration in rats.
References O’Dell, L.E. et al.: Pharmacol. Biochem. Behav., 81, 543 (2005); Engel, S.R. et al.: J. Pharmacol. Exp. Ther., 297, 489 (2001); Shannon, E.E. et al.: Alcohol, 37, 35 (2005);

• Brand: TRC

Chemical properties

• Molecular weight: 318.49
• Formula: C₂₁H₃₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16+,17-,18+,19+,20+,21-/m1/s1
• InChI key: InChIKey=AURFZBICLPNKBZ-GRWISUQFSA-N
• SMILES: CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C