Epirubicin Glucuronide Sodium Salt (α/β mixture)

CAS: 92137-84-3

Ref. TR-E588665

Product Information

• Name: Epirubicin Glucuronide Sodium Salt (α/β mixture)
• Synonyms: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-4-O-D-glucopyranuronosyl-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Sodium Salt, (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-4-O-D-glucopyranuronosyl-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy- 5,12-naphthacenedione Sodium Salt, 4'-O-D-Glucuronyl-4'-epirubicin Sodium Salt
• Brand: TRC
• Description: Applications Epirubicin glucuronide is a prodrug and a metabolite of Epirubicin (HCl: E588650). Epirubicin is an antineoplastic agent that is used as primary treatment for advanced breast cancer. Epirubicin is also used in conjunction with other cytotoxic agents to treat a number of cancerous malignancies such as ovarian cancer.References Cersosimo, R. & Hong, W.: J. Clin. Oncol., 4, 425 (1986); Focan, C., et al.: J. Clin. Oncol., 11, 1253 (1993); Houba, P., et al.: Biochem. Pharm., 52, 455 (1996); Innocenti, F., et al.: Drug Metab. Disp., 29, 686 (2001); Plosker, G. & Faulds, D.: Drugs, 45, 788 (1993)

Chemical properties

• Molecular weight: 741.625
• Formula: C₃₃H₃₆NNaO₁₇
• Color/Form: Neat
• InChI: InChI=1S/C33H37NO17.Na/c1-10-29(50-32-28(43)26(41)27(42)30(51-32)31(44)45)13(34)6-17(48-10)49-15-8-33(46,16(36)9-35)7-12-19(15)25(40)21-20(23(12)38)22(37)11-4-3-5-14(47-2)18(11)24(21)39;/h3-5,10,13,15,17,26-30,32,35,38,40-43,46H,6-9,34H2,1-2H3,(H,44,45);/q;+1/p-1/t10-,13-,15-,17-,26+,27+,28-,29-,30+,32?,33-;/m0./s1
• InChI key: InChIKey=HSFQMIWRFPBXNN-WEFWUAMYSA-M
• SMILES: COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](OC2O[C@@H](C(=O)O[Na])[C@H](O)[C@@H](O)[C@@H]2O)[C@H](C)O1