Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161798-03-4

Ref. TR-E702955

Product Information

• Name: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
• Synonyms: 2-[3-Formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic Acid Ethyl Ester, Febuxostat Impurity, 2-[3-Formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid ethyl ester, 5-Thiazolecarboxylic acid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester, Ethyl 2-(3-formyl-4-iso butoxyphenyl)-4-methylthiazole-5-carboxylate, Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5- Thiazolecarboxylate, Ethyl 2-[3-Formyl-4-(2-Methylpropoxy)Phenyl]-4-Methyl-1,3-Thiazole-5-Carboxylate, Ethyl-2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylate, Febuxostat N-4

Description

Applications Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.
References Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005);

• Brand: TRC

Chemical properties

• Molecular weight: 347.43
• Formula: C₁₈H₂₁NO₄S
• Color/Form: Neat
• InChI: InChI=1S/C18H21NO4S/c1-5-22-18(21)16-12(4)19-17(24-16)13-6-7-15(14(8-13)9-20)23-10-11(2)3/h6-9,11H,5,10H2,1-4H3
• InChI key: InChIKey=AIQMFFCWDAIGNV-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1sc(-c2ccc(OCC(C)C)c(C=O)c2)nc1C