Eurycomanone

CAS: 84633-29-4

Ref. TR-E939010

Product Information

• Name: Eurycomanone
• Synonyms: 1,20-Epoxy-1,11,12,14,15-pentahydroxy-(1β,11β,12α,15β)-Picrasa-3,13(21)-diene-2,16-dione, NSC 339187, Pasakbumin A, (1β,11β,12α,15β)-11,20-Epoxy-1,11,12,14,15-pentahydroxypicrasa-3,13(21)-diene-2,16-dione, Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)-, 2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran, picrasa-3,13(21)-diene-2,16-dione deriv.

Description

Applications Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.
References Wong, P.F., et al.: Phytomed., 19, 138 (2012); Nurkhasanah, M., et al., Medunion Press., 4, 109 (2008); Zakaria, Y., et al.: Cancer Cell Intern., 9, (2009);

• Brand: TRC

Chemical properties

• Molecular weight: 444.43
• Formula: C₂₀H₂₄O₉H₂O
• Purity: >90%
• Color/Form: Neat
• InChI: InChI=1S/C20H24O9.2H2O/c1-7-4-10(21)13(23)17(3)9(7)5-11-18-6-28-20(27,16(17)18)12(22)8(2)19(18,26)14(24)15(25)29-11;;/h4,9,11-14,16,22-24,26-27H,2,5-6H2,1,3H3;2*1H2/t9-,11+,12+,13+,14-,16+,17+,18+,19-,20-;;/m0../s1
• InChI key: InChIKey=UCUWZJWAQQRCOR-OKNZMGBLSA-N
• SMILES: C=C1[C@@H](O)[C@]2(O)OC[C@@]34[C@@H](C[C@H]5C(C)=CC(=O)[C@@H](O)[C@]5(C)[C@@H]23)OC(=O)[C@H](O)[C@@]14O