Fenoverine

CAS: 37561-27-6

Ref. TR-F248898

Product Information

• Name: Fenoverine
• Synonyms: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)ethanone, 10-[[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]acetyl]-10H-phenothiazine, Spasmopriv, 10-((4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)acetyl)-10H-phenothiazine, 10-((4-Piperonyl-1-piperazinyl)acetyl)phenothiazine, 10H-Phenothiazine, 10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)acetyl)-, 2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-phenothiazin-10-yl-ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-(10H-phenothiazin-10-yl)ethanone, Ethanone, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-1-(10H-phenothiazin-10-yl)-, Fenoverina, Fenoverina [INN-Spanish], Fenoverine [INN:DCF], Fenoverinum, Fenoverinum [INN-Latin], Unii-N274Zq6Pzj

Description

Applications Fenoverine is a colon-specific multi particulate drug. Also, it is an antispasmodic drug which inhibits contraction of smooth muscle. It is derived from Phenothiazine (P318040), which is a key component of antipsychotic and antihistaminic drugs.
References Diddi, S., et al.: Int. J. Pharm. Pharm. Sci., 6, 227-231 (2014); Deodhar, P., et al.: J. Pharm. Res., 5, 3406-3409 (2012); Bansode, T., et al.: Eur. J. Med. Chem., 44, 5094 (2009), Baell, J., et al.: J. Med. Chem., 53, 2719 (2010), Howard, P., et al.: Environ. Sci. Technol., 44, 2277 (2010), Koren, J., et al.: J. Biol. Chem., 285, 2498 (2010), Amobi, N., et al.: Eur. J. Pharmacol., 627, 285 (2010);

• Brand: TRC

Chemical properties

• Molecular weight: 459.56
• Formula: C₂₆H₂₅N₃O₃S
• Color/Form: Off-White To Beige
• InChI: InChI=1S/C26H25N3O3S/c30-26(29-20-5-1-3-7-24(20)33-25-8-4-2-6-21(25)29)17-28-13-11-27(12-14-28)16-19-9-10-22-23(15-19)32-18-31-22/h1-10,15H,11-14,16-18H2
• InChI key: InChIKey=UBAJTZKNDCEGKL-UHFFFAOYSA-N
• SMILES: O=C(CN1CCN(Cc2ccc3c(c2)OCO3)CC1)N1c2ccccc2Sc2ccccc21