Filipin III

CAS: 480-49-9

Ref. TR-F337003

Product Information

• Name: Filipin III
• Synonyms: Oxacyclooctacosane, Filipin III deriv., 14-Deoxylagosin, 15-Deoxylagosin, 1',26-Dihydroxyfilipin I, 1'-Hydroxyfilipin II, 1'-epi-Filipin IV, Filimarisin, NSC 3364, NSC 38092, [3R-[3R*(R*),4S*,6S*,8S*,10R*,12R*,14R*,16S*,17E,19E,21E,23E,25E,27S*,28R*]]-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
• Brand: TRC
• Description: Applications Filipin III is a cholesterol-binding, fluorescing antibiotic. Also, it is a pentaene macrolide produced by Streptomyces filipinensis, widely used for the detection and quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann-Pick type C disease;Polyene antibiotic, most extensively used tool for the specific detection of fluorescently labeled 3-β-hydroxysterols.References Payero, T. D., et al.: Microb. Cell Fact., 14, 1-14 (2015); Stanislas, T., et al.: Methods Mol. Biol., 1209, 13-29 (2014)

Chemical properties

• Molecular weight: 654.83
• Formula: C₃₅H₅₈O₁₁
• Color/Form: Neat
• InChI: InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14?/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
• InChI key: InChIKey=IMQSIXYSKPIGPD-YQRUMEKGSA-N
• SMILES: CCCCC[C@@H](O)[C@H]1C(=O)O[C@H](C)[C@@H](O)/C=C/C=C/C=C/C=C/C=C(\C)[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H]1O