6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-5,6-dihydro-4-hydroxy-2H-pyran-2-one

CAS:
920275-10-1

Ref. TR-F489645

Salts and Derivatives of Active Pharmaceutical Ingredients (API)

Product Information

Name:6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-5,6-dihydro-4-hydroxy-2H-pyran-2-one

Synonyms:

Fluvastatin EP Impurity E

Brand:TRC

Description:

Impurity Fluvastatin EP Impurity E
Applications 6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-5,6-dihydro-4-hydroxy-2H-pyran-2-one (Fluvastatin EP Impurity E) is an impurity of Fluvastatin (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.
References Yuan, J., et al.: Atherosclerosis, 87, 147 (1991), Tse, F.L.S., et al.: J. Clin. Pharmacol., 32, 630 (1992), Dain, J.G., et al.: Drug Metab. Disposit., 21, 567 (1993)

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Chemical properties

Molecular weight:391.43

Formula:C₂₄H₂₂FNO₃

Color/Form:Neat

InChI:InChI=1S/C24H22FNO3/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-19-13-18(27)14-23(28)29-19/h3-12,14-15,19,27H,13H2,1-2H3/b12-11+

InChI key:InChIKey=ZGDYKLKDTFTSJY-VAWYXSNFSA-N

SMILES:CC(C)n1c(/C=C/C2CC(O)=CC(=O)O2)c(-c2ccc(F)cc2)c2ccccc21

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