9a-Fluoro-11b,17a-dihydroxy-6-methylenepregna-1,4-diene-3,20-dione

Ref. TR-F489663

Product Information

• Name: 9a-Fluoro-11b,17a-dihydroxy-6-methylenepregna-1,4-diene-3,20-dione
• Synonyms: (8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11,17-dihydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• Brand: TRC

Description

Applications 9α-Fluoro-11β,17α-dihydroxy-6-methylenepregna-1,4-diene-3,20-dione is an intermediate in synthesizing 6β-Methyl Fluorometholone (M305340). It is an impurity in the synthesis of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.
References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982); Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984)

Chemical properties

• Molecular weight: 374.45
• Formula: C₂₂H₂₇FO₄
• Color/Form: Neat
• InChI: InChI=1S/C22H27FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,15,17-18,26-27H,1,6,8-9,11H2,2-4H3/t15-,17-,18-,19-,20-,21-,22-/m0/s1
• InChI key: InChIKey=VCBYDZMWTJNVPL-QWQRBHLCSA-N
• SMILES: C=C1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]2(C)C=CC(=O)C=C12