Fumaric Acid Monomethyl Ester

CAS: 2756-87-8

Ref. TR-F500390

Product Information

• Name: Fumaric Acid Monomethyl Ester
• Synonyms: Monomethyl Fumarate, (2E)-2-Butenedioic acid 1-methyl ester, (E)-2-Butenedioic acid monomethyl ester, Fumaric acid methyl ester, Methyl hydrogen fumarate, Monomethyl fumarate, (2E)-4-methoxy-4-oxobut-2-enoic acid, (2Z)-4-methoxy-4-oxobut-2-enoic acid, (E)-4-Methoxy-4-oxo-but-2-enoic acid, (E)-4-Methoxy-4-oxobut-2-enoic acid, 2-Butenedioic acid (2E)-, 1-methyl ester, 2-Butenedioic acid (2E)-, monomethyl ester, 2-Butenedioic acid (E)-, monomethyl ester, Fumaric acid monomethyl ester, Fumaric acid, methyl ester

Description

Applications Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric acid monomethyl ester is potent nicotinic acid receptor agonist. Fumaric acid monomethyl ester has also been shown to selectively stimulate of T helper 2 cytokine response. It is also the active metabolite of Dimethyl Fumarate (D464965), a compound that is used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.
References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008)

• Brand: TRC

Chemical properties

• Molecular weight: 130.10
• Formula: C₅H₆O₄
• Color/Form: Neat
• InChI: InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+