(3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

CAS: 287714-41-4

Ref. TR-F592040

Product Information

• Name: (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
• Synonyms: (3S,5S,7R)- Rosuvastatin Impurity I (EP) Sodium Salt
• Brand: TRC
• Description: Applications (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)

Chemical properties

• Molecular weight: 503.519
• Formula: C₂₂H₂₇FN₃NaO₆S
• Color/Form: Neat
• InChI: InChI=1S/C22H28FN3O6S.Na/c1-11(2)20-17-10-16(18(28)8-13(27)9-19(29)30)15-7-12(23)5-6-14(15)21(17)25-22(24-20)26(3)33(4,31)32;/h5-7,11,13,16,18,27-28H,8-10H2,1-4H3,(H,29,30);/q;+1/p-1/t13-,16+,18-;/m0./s1
• InChI key: InChIKey=KIRIQIQZEBQOEM-BIGNSGQMSA-M
• SMILES: CC(C)c1nc(N(C)S(C)(=O)=O)nc2c1C[C@@H]([C@@H](O)C[C@H](O)CC(=O)O[Na])c1cc(F)ccc1-2