Fluticasone Furoate

CAS: 397864-44-7

Ref. TR-F599510

Product Information

• Name: Fluticasone Furoate
• Synonyms: Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6a,11ß,16a,17a)-, 6a,9a-Difluoro-17a-[(2-furanylcarbonyl)oxy]-11ß-hydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17ß-carbothioic acid S-fluoromethyl ester, Allermist, Avamys, Furamist, GSK 685 698, GW 685698X, Veramyst, GW 685698X, CAF (GW694301X), GW 872664X, TAF (GW675713X), 6-des-fluoro 698 (GW836850X), Fluticasone Furoate (GW685698X), GSK465433A and GSK1322631A, 5-chloro-furoyl 698 (GSK180878A), TA-TAF dimer (GW871519X), GSK1042706A, GSK1103877A, GSK1322631A, Thioacid free acid (GR46580X), Thioacid furoate (GW675713X), Thioacid difuroate (GW725996X), (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl-2-furancarboxylate, 6alpha,9-Difluoro-17-(((fluoromethyl)sulfanyl)carbonyl)-11beta-hydroxy-16alpha-methyl-3-oxoandrosta-1,4-dien-17alpha-yl furan-2-carboxylate, 6α,9α-Difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid S-fluoromethyl ester, Alisade, Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-, Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6α,11β,16α,17α)-, Gsk 685 698, Gsk 685698, Gw 685698X, Unii-Js86977Wnv

Description

Applications A synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis.
References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),

• Brand: TRC

Chemical properties

• Molecular weight: 538.58
• Formula: C₂₇H₂₉F₃O₆S
• Color/Form: Neat
• InChI: InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
• InChI key: InChIKey=XTULMSXFIHGYFS-VLSRWLAYSA-N
• SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c1ccco1)C(=O)SCF