N-Fmoc-D-methionine

CAS: 112883-40-6

Ref. TR-F622850

Product Information

• Name: N-Fmoc-D-methionine
• Synonyms: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-methionine, (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid, (2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-4-(methylsulfanyl)butanoic acid, 291: PN: US20070042401 PAGE: 37 claimed protein, 9-Fluorenylmethoxycarbonyl-D-Methionine, 982: PN: WO2006135786 PAGE: 70 claimed protein, <span class="text-smallcaps">D</span>-FMOC-methionine, <span class="text-smallcaps">D</span>-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, Fmoc-D-Met, Fmoc-D-Met-OH, N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">D</span>-methionine, N-(9-Fluorenylmethoxycarbonyl)-D-Methionine, N-Alpha-(9-Fluorenylmethoxycarbonyl)-D-Methionine, N-Alpha-(9-Fluorenylmethyloxycarbonyl)-D-Methionine, N-Alpha-Fmoc-D-Methionine, N-Fmoc-D-Methionine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<span class="text-smallcaps">D</span>-methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]methionine, NALPHA-9-Fluorenylmethoxycarbonyl-D-methionine, D-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Description

Applications N-Fmoc-D-methionine is an N-Fmoc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

• Brand: TRC

Chemical properties

• Molecular weight: 371.45
• Formula: C₂₀H₂₁NO₄S
• Color/Form: Neat
• InChI: InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m1/s1
• InChI key: InChIKey=WNCUVUUEJZEATP-UHFFFAOYSA-N
• SMILES: COc1ccc(OC)c(CCN)c1