Product Information
Name:Freselestat
Controlled Product
Synonyms:
- 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
- ONO 6818
- ONO-PO 736
Brand:TRC
Description:Applications Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.References Ohbayashi, H.: IDrugs, 5, 910 (2002); Trifilieff, A.: Curr. Opin. Invest. Dr., 3, 1161 (2002); Ohmoto, K., et al.: Synlett, no vol., 299 (2001); Ohmoto, K., et al.: J. Med. Chem., 43, 4927 (2000)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:452.51
Formula:C23H28N6O4
Color/Form:Neat
InChI:InChI=1S/C23H28N6O4/c1-13(2)17(18(31)20-27-28-22(33-20)23(3,4)5)26-16(30)12-29-19(14-9-7-6-8-10-14)25-11-15(24)21(29)32/h6-11,13,17H,12,24H2,1-5H3,(H,26,30)
InChI key:InChIKey=YSIHYROEMJSOAS-UHFFFAOYSA-N
SMILES:CC(C)C(NC(=O)Cn1c(-c2ccccc2)ncc(N)c1=O)C(=O)c1nnc(C(C)(C)C)o1
Technical inquiry about: Freselestat
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