Product Information
Name:Fingolimod-d4 Hydrochloride
Controlled Product
Synonyms:
- 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride
- FTY720-d4 Hydrochloride
Brand:TRC
Description:Applications A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),
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Chemical properties
Molecular weight:347.96
Formula:C19H30D4ClNO2
Color/Form:Neat
InChI:InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H/i15D2,16D2;
InChI key:InChIKey=SWZTYAVBMYWFGS-JWIOGAFXSA-N
SMILES:Cl.[2H]C([2H])(O)C(N)(CCc1ccc(CCCCCCCC)cc1)C([2H])([2H])O
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