Fingolimod-d4 Hydrochloride

CAS: 1346604-90-7

Ref. TR-F805002

Product Information

• Name: Fingolimod-d4 Hydrochloride
• Synonyms: 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride, FTY720-d4 Hydrochloride

Description

Applications A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 347.96
• Formula: C₁₉H₃₀D₄ClNO₂
• Color/Form: Neat
• InChI: InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H/i15D2,16D2
• InChI key: InChIKey=SWZTYAVBMYWFGS-JWIOGAFXSA-N
• SMILES: Cl.[2H]C([2H])(O)C(N)(CCc1ccc(CCCCCCCC)cc1)C([2H])([2H])O