Estimated delivery in United States, on Friday 17 Jan 2025
Product Information
Name:
GBT 440
Synonyms:
- 2-Hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]benzaldehyde
- Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
- 2-hydroxy-6-{[2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl]methoxy}benzaldehyde
- Voxelotor
Description:
Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.
References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
337.37
Formula:
C19H19N3O3
Color/Form:
Neat
InChI:
InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3
InChI key:
InChIKey=FWCVZAQENIZVMY-UHFFFAOYSA-N
SMILES:
CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-G268015 GBT 440
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