Product Information
Name:GSK PERK Inhibitor
Controlled Product
Synonyms:
- 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
Brand:TRC
Description:Applications GSK PERK Inhibitor is an inhibitor of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways. As a result, GSK PERK Inhibitor has potential use in the treatment of diseases such as Alzheimer's disease, stroke, Type 1 diabetes, Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung.References Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007); Axten, J. M.et al,: J. Med. Chem. 55(16) 7193 (2012).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:469.43
Formula:C24H19F4N5O
Color/Form:Neat
InChI:InChI=1S/C24H19F4N5O/c1-32-11-18(21-22(29)30-12-31-23(21)32)14-2-3-19-15(9-14)4-5-33(19)20(34)8-13-6-16(24(26,27)28)10-17(25)7-13/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,29,30,31)
InChI key:InChIKey=PXVQGBJMIQCDEX-UHFFFAOYSA-N
SMILES:Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21
Technical inquiry about: GSK PERK Inhibitor
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