Harmine

CAS: 442-51-3

Ref. TR-H105250

Product Information

• Name: Harmine
• Synonyms: 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, Banisterin, Banisterine, Harmin, Leucoharmine, Telepathin, Telepathine, Yagein, Yageine, 1-Methyl-7-methoxy-beta-carboline, 1-Methyl-7-methoxy-ß-carboline, 1-Methyl-7-methoxy-β-carboline, 7-Methoxy-1-methyl-9H-beta-carbolin, 7-Methoxy-1-methyl-9H-beta-carboline, 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, Banisterine Monohydrate

Description

Applications Harmine is a natural β-carboline alkaloid and a CNS stimulant (1,2). Harmine has been shown to be a potent and selective inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) (3). DYRK1A is a potential therapeutic target for treating diabetes, Down Syndrome, and HIV (4).
References (1) DiStefano, S., et al.: J. Pharmacol. Exp. Ther., 174, 456 (1970)(2) Dos Santos, R. G. and Hallak, J. E. J Psychoactive Drugs. 5,1 (2016) (3) Atteya, R., et al.: Mech Ageing Dev. 6, S0047 (2016)(4) Bol, S. M., et al.: PLoS One. 6, e17190 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 212.25
• Formula: C₁₃H₁₂N₂O
• Color/Form: White To Brown
• InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
• InChI key: InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1)[nH]c1c(C)nccc12