(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol

CAS: 156928-09-5

Ref. TR-H291095

Product Information

• Name: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol
• Synonyms: [3R-(3alpha,3abeta,6abeta)]-Hexahydrofuro[2,3-b]furan-3-ol, R,S,R-Bisfuran Alcohol
• Brand: TRC
• Description: Applications (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol is used as a reagent in the synthesis of Darunavir (D193500); a second generation HIV-1-protease inhibitor and antiviral agent.References Canoy, W.L., et al.: Org. Lett., 10, 1103 (2008); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)

Chemical properties

• Molecular weight: 130.14
• Formula: C₆H₁₀O₃
• Color/Form: Neat
• InChI: InChI=1S/C6H10O3/c7-5-3-9-6-4(5)1-2-8-6/h4-7H,1-3H2/t4-,5-,6+/m0/s1
• InChI key: InChIKey=RCDXYCHYMULCDZ-HCWXCVPCSA-N
• SMILES: O[C@H]1CO[C@H]2OCC[C@@H]12