HU 211

CAS: 112924-45-5

Ref. TR-H673505

Product Information

• Name: HU 211
• Synonyms: (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, (+)-Hu-210, (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol, (6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 6H-Dibenzo[b,d]pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS,10aS)-, 6H-Dibenzo[b,d]pyran-9-methanol, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-, (6aS-trans)-, Dexanabinol, Hu 211, Prs 211007-000, Sinnabidiol

Description

Applications HU-211 is a synthetic cannabinoid derivative that inhibits TNFα and interleukin-6 (1,2,3). HU-211 exhibits neuroprotective, antioxidant, and anti-inflammatory properties. It might be a useful agent for the treatment of stroke patients, by protecting neuronal lysosomes from nitric oxide (NO)-mediated toxicity.
References (1) Shohami, E., et al.: J. Neuroimmunol., 72, 169 (1997)(2) Ramazan, D., et al.: Neuochemical Res., 33, 1683 (2008) (3) Leker, R., et al.: J. Neurol. Sci., 162, 114 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 386.57
• Formula: C₂₅H₃₈O₃
• Color/Form: Neat
• InChI: InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m0/s1
• InChI key: InChIKey=SSQJFGMEZBFMNV-PMACEKPBSA-N
• SMILES: CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)[C@H]1CC=C(CO)C[C@H]21