Hydrocortisone 17-Butyrate 21-Propionate

CAS: 72590-77-3

Ref. TR-H714665

Product Information

• Name: Hydrocortisone 17-Butyrate 21-Propionate
• Synonyms: (11ß)-11-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)-pregn-4-ene-3,20-dione, 17a-Butyryloxy-11ß-hydroxy-21-propionyloxy-4-pregnene-3,20-dione, Hydrocortisone buteprate, Hydrocortisone probutate, Pandel, TS 408, (11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate, (11β)-11-Hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)pregn-4-ene-3,20-dione, (9Xi,11Beta)-11-Hydroxy-3,20-Dioxo-21-(Propanoyloxy)Pregn-4-En-17-Yl Butanoate, 17α-Butyryloxy-11β-hydroxy-21-propionyloxy-4-pregnene-3,20-dione, Hydrocortisone 17-butyrate 21-propionate, Hydrocortisone Probutate, Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-(1-oxopropoxy)-, (11β)-, Ts 408

Description

Applications A synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agents. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis.
References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981);

• Brand: TRC

Chemical properties

• Molecular weight: 488.61
• Formula: C₂₈H₄₀O₇
• Color/Form: White To Off-White
• InChI: InChI=1S/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1
• InChI key: InChIKey=FOGXJPFPZOHSQS-AYVLZSQQSA-N
• SMILES: CCCC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C