Hydrocortisone 21-Propionate

CAS: 6677-98-1

Ref. TR-H714775

Product Information

• Name: Hydrocortisone 21-Propionate
• Synonyms: Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(1-oxopropoxy)-, (11ß)-, Cortisol, 21-propionate (6CI,7CI,8CI), Hydrocortisone propionate, (11beta)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl propionate, Cortisol, 21-propionate, Pregn-4-Ene-3,20-Dione, 11,17-Dihydroxy-21-(1-Oxopropoxy)-, (11Beta)-

Description

Applications Hydrocortisone 21-Propionate is a metabolite of Hydrocortisone 17-Butyrate 21-Propionate (H714665); a synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agent. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis.
References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981); Kitano, Y., et al.: Acta Derm-Venereol., 66, 98 (1986)

• Brand: TRC

Chemical properties

• Molecular weight: 418.52
• Formula: C₂₄H₃₄O₆
• Color/Form: Neat
• InChI: InChI=1S/C24H34O6/c1-4-20(28)30-13-19(27)24(29)10-8-17-16-6-5-14-11-15(25)7-9-22(14,2)21(16)18(26)12-23(17,24)3/h11,16-18,21,26,29H,4-10,12-13H2,1-3H3/t16-,17-,18-,21+,22-,23-,24-/m0/s1
• InChI key: InChIKey=MRECAIZOMKKXOZ-KXTMDGJESA-N
• SMILES: CCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]21C