42-O-[2-[[Hydroxy(2-bromoethoxy)phosphinyl]oxy]ethyl] Rapamycin (Technical Grade)

Ref. TR-H818200

Product Information

• Name: 42-O-[2-[[Hydroxy(2-bromoethoxy)phosphinyl]oxy]ethyl] Rapamycin (Technical Grade)

Description

Applications Rapamycin (R124000(P)) derivative. Rapamycin a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.
References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 1145.153
• Formula: C₅₅H₈₇BrNO₁₇P
• Color/Form: Neat
• InChI: InChI=1S/C55H87BrNO17P/c1-34-16-12-11-13-17-35(2)46(67-8)32-42-21-19-40(7)55(64,74-42)52(61)53(62)57-24-15-14-18-43(57)54(63)73-47(33-44(58)36(3)29-39(6)50(60)51(69-10)49(59)38(5)28-34)37(4)30-41-20-22-45(48(31-41)68-9)70-26-27-72-75(65,66)71-25-23-56/h11-13,16-17,29,34,36-38,40-43,45-48,50-51,60,64H,14-15,18-28,30-33H2,1-10H3,(H,65,66)/b13-11+,16-12+,35-17+,39-29+/t34-,36?,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,55-/m1/s1
• InChI key: InChIKey=JOYXFFZTJWSXQM-FSOVVNODSA-N
• SMILES: CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCOP(=O)(O)OCCBr)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C