(-)-Huperzine A-d7 major (>90%)

CAS: 102518-79-6

Ref. TR-H826006

Product Information

• Name: (-)-Huperzine A-d7 major (>90%)
• Synonyms: (5R,9R,11E)-5-Amino-11-(ethylidene-2,2,2-d3)-5,6,9,10-tetrahydro-7-(methyl-d3-)-5,9-methanocycloocta[b]pyridin-2(1H)-one-d7, (11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one, (5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one, (5S,9S,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one, 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-, 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, [5R-(5α,9β,11E)]-, Hup A, Huperazine A(Sh), Huperzia Serrata Extract, Huperzine, Hupzine A, Kimpukan A, Selagine

Description

Applications (-)-Huperzine A-d7 major (>90%) is the labelled form of (-)-Huperzine A (H826000), a reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
References Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)

• Brand: TRC

Chemical properties

• Molecular weight: 249.359
• Formula: C₁₅D₇H₁₁N₂O
• Purity: >90%
• Color/Form: Neat
• InChI: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1/i2D3,5D,6D,7D2
• InChI key: InChIKey=ZRJBHWIHUMBLCN-UWCUZVGFSA-N
• SMILES: [2H]C1=C(C([2H])([2H])[2H])C[C@@]2(N)/C(=C/C)[C@@H]1C([2H])([2H])c1[nH]c(=O)c([2H])cc12