CAS 102518-79-6

Huperzine-A

Description:

Huperzine A is a naturally occurring alkaloid extracted from the Chinese club moss Huperzia serrata. It is primarily recognized for its potential neuroprotective properties and its role as a reversible inhibitor of the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This inhibition can enhance cholinergic transmission, making Huperzine A of interest in the context of cognitive enhancement and the treatment of neurodegenerative diseases such as Alzheimer's disease. The compound has a molecular formula of C15H18N2O and features a bicyclic structure that contributes to its biological activity. Huperzine A is typically administered in supplement form and is noted for its relatively low toxicity profile. Research indicates that it may also possess antioxidant properties and could support memory and learning functions. However, while promising, further clinical studies are necessary to fully understand its efficacy and safety in long-term use. As with any supplement, it is advisable to consult healthcare professionals before use, especially for individuals with underlying health conditions or those taking other medications.

Formula: C₁₅H₁₈N₂O

InChI: InChI=1/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1

InChI key: InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N

SMILES: N[C@@]\12C3=C(C[C@@](/C1=C\C)(C=C(C)C2)[H])NC(=O)C=C3

Synonyms:

• (11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
• (5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
• (5S,9S,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
• 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
• 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, [5R-(5α,9β,11E)]-
• Hup A
• Huperazine A(Sh)
• Huperzia Serrata Extract
• Huperzine
• Hupzine A
• Kimpukan A
• Selagine
• Huperzine A
• (+-)-huperzine A
• (-) Huperzine A
• Huperzine A
• (-)-Huperzine A
• HUPERZINE A 1%
• HUPERIZINE
• (5R,11E)-5β-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5α,9α-methanocycloocta[b]pyridin-2(1H)-one
• Huperzine A ( Selagine )
• (-)-HUPERZINE A FROM HUPERZIA SERRATA
• 5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah
• Huperzine-A1-5%
• HUP, [5R-(5a,911E)]-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2-(1H)-one, Selagine,
• HuperziaSerrateP.E120786-18-7/
• Huperizine A
• (-)-HUPERZINE A, 99% HPLC
• 5,9-Methanocyclooctabpyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
• (5r-(5-alpha,9-beta,11e))-ydro-7-methyl
• 5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one

(-)-Huperzine A

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 242.32

Ref: 3B-H1700

(-)-Huperzine A

CAS: 102518-79-6

(-)-Huperzine A

Formula: C₁₅H₁₈N₂O

Purity: 99%

Molecular weight: 242.32

Ref: 54-BUP13661

(-)-Huperzine A

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 242.32

Ref: 4Z-H-171

(-)-Huperzine A (Standard)

CAS: 102518-79-6

(-)-Huperzine A (Standard) is a reference standard for research and analysis in studies involving (-)-Huperzine A. (-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

Formula: C₁₅H₁₈N₂O

Color and Shape: Solid

Molecular weight: 242.32

Ref: TM-TMSM-2788

Huperzine A

CAS: 102518-79-6

(-)-Huperzine A is a naturally occurring potent reversible AChE inhibitor that penetrates the blood-brain barrier, it also has several neuroprotective effects including modification of beta-amyloid peptide, reduction of oxidative stress, anti-inflammatory, anti-apoptotic and induction and regulation of nerve growth factor.

Formula: C₁₅H₁₈N₂O

Purity: 95%~99%

Molecular weight: 242.322

Ref: BP-BP0740

(-)-Huperzine A-d7 major (>90%)

Controlled Product

CAS: 102518-79-6

Applications (-)-Huperzine A-d7 major (>90%) is the labelled form of (-)-Huperzine A (H826000), a reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
References Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)

Formula: C₁₅D₇H₁₁N₂O

Purity: >90%

Color and Shape: Neat

Molecular weight: 249.359

Ref: TR-H826006

(-)-Huperzine A

Controlled Product

CAS: 102518-79-6

Applications Reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)

Formula: C₁₅H₁₈N₂O

Color and Shape: Neat

Molecular weight: 242.32

Ref: TR-H826000

(-)-Huperzine A

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Purity: ≥ 98.0%

Color and Shape: White or off-white powder

Molecular weight: 242.32

Ref: 7W-GK8768

(5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one

CAS: 102518-79-6

(5R,9R,E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one

Formula: C₁₅H₁₈N₂O

Purity: 98%

Molecular weight: 242.32

Ref: IN-DG7739

(-)-Huperzine A

CAS: 102518-79-6

(-)-Huperzine A: Lycopodium alkaloid, AChE inhibitor, treats Alzheimer's in China.

Formula: C₁₅H₁₈N₂O

Purity: 99.19% - >99.99%

Color and Shape: Solid

Molecular weight: 242.32

Ref: TM-T3026

Huperzine A

CAS: 102518-79-6

Natural alkaloid

Formula: C₁₅H₁₈N₂O

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 242.32

Ref: 5G-89313

(-)-Huperzine A

CAS: 102518-79-6

Acetylcholinesterase inhibitor; therapy for Alzheimer's disease

Formula: C₁₅H₁₈N₂O

Purity: (%) Min. 98%

Color and Shape: Powder

Molecular weight: 242.32 g/mol

Ref: 3D-FH09767

(-)-Huperzine A

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Molecular weight: 242.32

Ref: BE-RMCH068001

Huperzine A

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Molecular weight: 242.32

Ref: BE-RMT12235

(-)-Huperzine A-d6 (Major)

Controlled Product

CAS: 102518-79-6

Formula: C₁₅H₁₁D₇N₂O

Color and Shape: Neat

Molecular weight: 248.35

Ref: TR-H826002

(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one

CAS: 102518-79-6

Formula: C₁₅H₁₈N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 242.3162

Ref: IN-DA0007MO