4-Hydroxy Atorvastatin-d5 Disodium Salt

CAS: 1276537-18-8

Ref. TR-H828962

Product Information

• Name: 4-Hydroxy Atorvastatin-d5 Disodium Salt
• Synonyms: (ßR,dR)-2-(4-Fluorophenyl)-ß,d-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Disodium Salt, BMS 241423-01, PD 142542, p-Hydroxyatorvastatin

Description

Stability Hygroscopic
Applications A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 623.63
• Formula: C₃₃H₂₈D₅FN₂Na₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C33H35FN2O6.2Na/c1-20(2)31-30(33(42)35-24-12-14-25(37)15-13-24)29(21-6-4-3-5-7-21)32(22-8-10-23(34)11-9-22)36(31)17-16-26(38)18-27(39)19-28(40)41;;/h3-15,20,26-27,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41);;/q;2*+1/p-2/t26-,27-;;/m1../s1/i3D,4D,5D,6D,7D
• InChI key: InChIKey=LTONRNZYFYCVRP-BRHLTBDCSA-L
• SMILES: [2H]c1c([2H])c([2H])c(-c2c(C(=O)Nc3ccc(O[Na])cc3)c(C(C)C)n(CC[C@@H](O)C[C@@H](O)CC(=O)O[Na])c2-c2ccc(F)cc2)c([2H])c1[2H]