Hydroxy Bosentan-d4

CAS: 1065472-91-4

Ref. TR-H830272

Product Information

• Name: Hydroxy Bosentan-d4
• Synonyms: 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide, Ro 48-8634-d4, Ro 48-5033-d4
• Brand: TRC
• Description: Applications A labelled analogue of the active metabolite of Bosentan, a mixed endothelin receptor antagonist which is used as a vasodilator.References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Chemical properties

• Molecular weight: 571.64
• Formula: C₂₇₂H₄H₂₅N₅O₇S
• Color/Form: Neat
• InChI: InChI=1S/C27H29N5O7S/c1-27(2,17-34)18-9-11-19(12-10-18)40(35,36)32-23-22(39-21-8-5-4-7-20(21)37-3)26(38-16-15-33)31-25(30-23)24-28-13-6-14-29-24/h4-14,33-34H,15-17H2,1-3H3,(H,30,31,32)/i15D2,16D2
• InChI key: InChIKey=FAJQMBCLPZWTQJ-ONNKGWAKSA-N
• SMILES: [2H]C([2H])(O)C([2H])([2H])Oc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)CO)cc2)c1Oc1ccccc1OC