Hydroxy Cyclophosphamide Semicarbazone (80%)
CAS: 53948-46-2
Ref. TR-H926305
25mg | 1,753.00 € | ||
2500µg | 259.00 € |
Product Information
- N,N-bis(2-chloroethyl)phosphorodiamidic Acid 3-[2-(Aminocarbonyl)hydrazinylidene]propyl Ester
- NSC 319519
- Aldophosphamide Semicarbazone
Applications Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.
References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962); Fraiser, L.H., et al.: Drugs, 42, 781 (1991); Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999);
Chemical properties
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