Product Information
Name:Hydroxy Cyclophosphamide Semicarbazone (80%)
Controlled Product
Synonyms:
- N,N-bis(2-chloroethyl)phosphorodiamidic Acid 3-[2-(Aminocarbonyl)hydrazinylidene]propyl Ester
- NSC 319519
- Aldophosphamide Semicarbazone
Brand:TRC
Description:Applications Aldophosphamide Semicarbazone is a major metabolite of cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.References Struck, R.F., et al.: Cancer. Rsch., 34, 2933 (1947); Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962); Fraiser, L.H., et al.: Drugs, 42, 781 (1991); Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999);
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Chemical properties
Molecular weight:334.14
Formula:C8H18Cl2N5O3P
Purity:80%
Color/Form:Neat
InChI:InChI=1S/C8H18Cl2N5O3P/c9-2-5-15(6-3-10)19(12,17)18-7-1-4-13-14-8(11)16/h4H,1-3,5-7H2,(H2,12,17)(H3,11,14,16)/b13-4+
InChI key:InChIKey=DDSWASMKEIRTLV-YIXHJXPBSA-N
SMILES:NC(=O)N/N=C/CCOP(N)(=O)N(CCCl)CCCl
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