(R)-Hydroxy Des(boric Acid) Bortezomib

CAS: 289472-78-2

Ref. TR-H935900

Product Information

• Name: (R)-Hydroxy Des(boric Acid) Bortezomib
• Synonyms: 2-Pyrazinecarboxamide, N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, Pyrazinecarboxamide, N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]- (9CI), N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide, (S,R)-Bortezomib hydroxyisopentyl amide analog (USP)

Description

Impurity Bortezomib USP Impurity I
Applications (R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C. et al.: Chem. and Eng. News, 87, 41 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 356.42
• Formula: C₁₉H₂₄N₄O₃
• Color/Form: Neat
• InChI: InChI=1S/C19H24N4O3/c1-13(2)10-17(24)23-18(25)15(11-14-6-4-3-5-7-14)22-19(26)16-12-20-8-9-21-16/h3-9,12-13,15,17,24H,10-11H2,1-2H3,(H,22,26)(H,23,25)/t15-,17+/m0/s1
• InChI key: InChIKey=NEIDLJIPMZVISC-MYJWUSKBSA-N
• SMILES: CC(C)CC(O)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1