2-Hydroxyisoquinoline-1,3(2H,4H)-dione
CAS: 6890-08-0
Ref. TR-H939800
| 10mg | 176.00 € | ||
| 25mg | 340.00 € | ||
| 100mg | 1,119.00 € |
Product Information
- 2-hydroxy-4H-isoquinoline-1,3-dione
- 1,3(2H,4H)-Isoquinolinedione, 2-hydroxy-
Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.
References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),
Chemical properties
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