6-Hydroxy Dopamine Hydrobromide

CAS: 636-00-0

Ref. TR-H941730

Product Information

• Name: 6-Hydroxy Dopamine Hydrobromide
• Synonyms: 5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide, 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide, 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1), 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 5-(2-Aminoethyl)-4-Hydroxypyrocatechol Hydrobromide, 5-(2-Aminoethyl)Benzene-1,2,4-Triol Hydrobromide (1:1), 6-Hydroxydopamine hydrogen bromide, 6-Hydroxydopamine hydrobromide

Description

Stability Hygroscopic, Light Sensitive
Applications 6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
References Soto-Otero, R. et al.: J. Neurochem., 74, 1605 (2000); Fujita, H. et al.: Brain Res., 1113, 10 (2006); Breese, G.R. et al.: 174, 313 (1970);

• Brand: TRC

Chemical properties

• Molecular weight: 250.09
• Formula: C₈H₁₁NO₃·BrH
• Color/Form: Neat
• InChI: InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• InChI key: InChIKey=MLACDGUOKDOLGC-UHFFFAOYSA-N
• SMILES: Br.NCCc1cc(O)c(O)cc1O