3-Hydroxy-2-naphthoic Acid-d6

CAS: 92-70-6

Ref. TR-H951079

Product Information

• Name: 3-Hydroxy-2-naphthoic Acid-d6
• Synonyms: 1,4,5,6,7,8-hexadeuterio-3-hydroxynaphthalene-2-carboxylic acid
• Brand: TRC

Description

Applications 3-Hydroxy-2-naphthoic Acid-d6 is an intermediate used in the synthesis of Pamoic Acid-d10 (P173502), which is a labelled Pamoic Acid. Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases. Enzyme replacement therapy in pancreatic enzyme deficiency.
References Fonge H., et al.: Bioconjugate Chem., 18, 1924 (2007), Mayr, G.W., et al.: J. Biol. Chem., 282, 35424 (2007); Zhao, P. et al.: Mol. Pharmacol., 78, 560 (2010); Dorjsujen, D. et al.: Nuc. Acids Res., 37, e128 (2009);

Chemical properties

• Molecular weight: 194.216
• Formula: C₁₁D₆H₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C11H8O3/c12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h1-6,12H,(H,13,14)/i1D,2D,3D,4D,5D,6D
• InChI key: InChIKey=ALKYHXVLJMQRLQ-MZWXYZOWSA-N
• SMILES: [2H]c1c([2H])c([2H])c2c([2H])c(C(=O)O)c(O)c([2H])c2c1[2H]