9-(2-Hydroxypropyl)adenine

CAS: 14047-26-8

Ref. TR-H952010

Product Information

• Name: 9-(2-Hydroxypropyl)adenine
• Synonyms: 6-Amino-alpha-methyl-9H-purine-9-ethanol, (RS)-9-(2-Hydroxypropyl)adenine, 9-(2-Hydroxyprop-1-yl)adenine, DL-9-(2-Hydroxypropyl)adenine, DL-6-Amino-alpha-methyl-9H-purine-9-ethanol, (±)-DL-6-Amino-alpha-methyl-9H-purine-9-ethanol

Description

Applications 9-(2-Hydroxypropyl)adenine is the unlabeled form of 9-(2-Hydroxypropyl)adenine-13C5 (H952012), which is an intermediate used in the synthesis of rac Tenofovir-13C5 (>90%) (T018501), the isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

• Brand: TRC

Chemical properties

• Molecular weight: 193.21
• Formula: C₈H₁₁N₅O
• Color/Form: Neat
• InChI: InChI=1S/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)
• InChI key: InChIKey=MJZYTEBKXLVLMY-UHFFFAOYSA-N
• SMILES: CC(O)Cn1cnc2c(N)ncnc21