4-Hydroxy-Teriflunomide

CAS: 1058722-45-4

Ref. TR-H956180

Product Information

• Name: 4-Hydroxy-Teriflunomide
• Synonyms: 2-Butenamide, 2-cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)- (ACI), (2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (ACI)
• Brand: TRC
• Description: Applications 4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

Chemical properties

• Molecular weight: 286.207
• Formula: C₁₂H₉F₃N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C12H9F3N2O3/c13-12(14,15)7-1-3-8(4-2-7)17-11(20)9(5-16)10(19)6-18/h1-4,18-19H,6H2,(H,17,20)/b10-9-
• SMILES: N#C/C(C(=O)Nc1ccc(C(F)(F)F)cc1)=C(/O)CO