Product Information
Name:I-BET 151
Controlled Product
Synonyms:
- 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydro-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-Imidazo[4,5-c]quinolin-2-one
Brand:TRC
Description:Applications I-BET 151 is part of a novel series of quinoline isoxazole BET family bromodomain inhibitors, a family of four proteins that selectively bind to aceylated lysine residues in histone. I-BET 151 play key roles in many cellular processes, including anti-inflammatory gene expression, mitosis, and viral/host interaction by controlling the conformation of histone acetylation -dependent chromatin complexes. Studies have shown that I-BET 151 increased ApoA1 expression within the nanomolar range in human hepatic cell line HepG2. The upregulation by I-BET 151 suggested potential anti-inflammatory activities upon administration. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Seal, J., et al.L Bioorg. Medn. Chem. Letters., 22, 2968 (2012); Mirguet, O., et al.: Bioorg. Medn. Chem. Letters, 22, 2963 (2012); Dawson, M.A., et al.: Nature., 478, 529 (2011);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:415.44
Formula:C23H21N5O3
Color/Form:Neat
InChI:InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChI key:InChIKey=VUVUVNZRUGEAHB-CYBMUJFWSA-N
SMILES:COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12
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