Estimated delivery in United States, on Tuesday 18 Feb 2025
Product Information
Name:
iCRT-14
Controlled Product
Synonyms:
- 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione
- iCRT14
Description:
Applications A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
References Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
375.44
Formula:
C21H17N3O2S
Color/Form:
Neat
InChI:
InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChI key:
InChIKey=NCSHZXNGQYSKLR-UNOMPAQXSA-N
SMILES:
Cc1cc(/C=C2\SC(=O)N(c3ccccc3)C2=O)c(C)n1-c1cccnc1
MDL:
Melting point:
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Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-I163900 iCRT-14
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