IDRA-21

CAS: 22503-72-6

Ref. TR-I232500

Product Information

• Name: IDRA-21
• Synonyms: 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide, Idra 21

Description

Applications IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer's disease.
References (1) Malkova, L, et al.: Neuropharmacology. 60, 1262 (2011)(2) Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999)(3) Sun, Y., et al.: Nature, 417, 245 (2002) (4) Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)

• Brand: TRC

Chemical properties

• Molecular weight: 232.69
• Formula: C₈H₉ClN₂O₂S
• Color/Form: Neat
• InChI: InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
• InChI key: InChIKey=VZRNTCHTJRLTMU-UHFFFAOYSA-N
• SMILES: CC1Nc2ccc(Cl)cc2S(=O)(=O)N1