Product Information
Name:IDRA-21
Controlled Product
Synonyms:
- 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide
Brand:TRC
Description:Applications IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer's disease.References (1) Malkova, L, et al.: Neuropharmacology. 60, 1262 (2011)(2) Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999)(3) Sun, Y., et al.: Nature, 417, 245 (2002) (4) Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:232.69
Formula:C8H9ClN2O2S
Color/Form:Neat
InChI:InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
InChI key:InChIKey=VZRNTCHTJRLTMU-UHFFFAOYSA-N
SMILES:CC1Nc2ccc(Cl)cc2S(=O)(=O)N1
Technical inquiry about: IDRA-21
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