5-Iodouracil

CAS: 696-07-1

Ref. TR-I728900

Product Information

• Name: 5-Iodouracil
• Synonyms: 5-Iodo-2,4(1H,3H)-pyrimidinedione, 5-Iodo-2,4-dihydroxypyrimidine, 5-Iodo-2,4-pyrimidinedione, 5-Iodopyrimidine-2,4-diol, NSC 57848, 2,4(1H,3H)-Pyrimidinedione, 5-iodo-, 2,4-Dihydroxy-5-Iodopyrimidine, 3H)-Pyrimidinedione,5-Iodo-4(1H, 5-I-U, 5-Iodo-Uraci, 5-iodopyrimidine-2,4(1H,3H)-dione, 5IU, Uracil, 5-iodo-

Description

Applications 5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
References Meisenheimer, K. et al.: Meth. Enzymol., 318, 88 (2000); Klecker, R.W. Jr. et al.: Cancer Chemother. Pharmacol., 48, 407 (2001); Turner, D.P. et al.: Cancer Res., 66, 7686 (2006);

• Brand: TRC

Chemical properties

• Molecular weight: 237.98
• Formula: C₄H₃IN₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• InChI key: InChIKey=KSNXJLQDQOIRIP-UHFFFAOYSA-N
• SMILES: Oc1ncc(I)c(O)n1