2-Isobutyryl-N-phenyl-3-phenylacrylamide

CAS: 265989-32-0

Ref. TR-I781042

Product Information

• Name: 2-Isobutyryl-N-phenyl-3-phenylacrylamide
• Synonyms: 4-Methyl-3-oxo-N-(phenyl-d5)-2-(phenylmethylene)pentanamide

Description

Applications 2-Isobutyryl-N-phenyl-3-phenylacrylamide is the labeled analogue of 2-Isobutyryl-N-phenyl-3-phenylacrylamide (I781040), an intermediate for the synthesis of Atorvastatin-d5 Sodium Salt (A791753), the labeled analogue of Atorvastatin (A791750) (1,2,3). Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993) (2) Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996) (3) Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

• Brand: TRC

Chemical properties

• Molecular weight: 298.39
• Formula: C₁₉H₁₄D₅NO₂
• Color/Form: Neat
• InChI: InChI=1S/C19H19NO2/c1-14(2)18(21)17(13-15-9-5-3-6-10-15)19(22)20-16-11-7-4-8-12-16/h3-14H,1-2H3,(H,20,22)/b17-13-/i4D,7D,8D,11D,12D
• InChI key: InChIKey=SMUFHBOCNIUNPT-LBAVIFQTSA-N
• SMILES: [2H]c1c([2H])c([2H])c(NC(=O)/C(=C\c2ccccc2)C(=O)C(C)C)c([2H])c1[2H]