Isoniazid

CAS: 54-85-3

Ref. TR-I821450

Product Information

• Name: Isoniazid
• Synonyms: pyridine-4-carbohydrazide, 4-(Hydrazinocarbonyl)pyridine, 4-(Hydrazinomethyl)Pyridine, 4-Pyridinecarbonylhydrazine, 4-Pyridylcarbonylhydrazide, Antimicina, Armazid, Armazide, Atcotibine, Cedin, Cotinazin, Dianicotyl, Dinacrin, Ditubin, Eralon, Ertuban, Eutizon, Gink, HIA, Hidranizil, Hidrasonil, Hycozid, Hydrazid, Hyzyd, Inah, Ipcazide, Isidrina, Isobicina, Isocaldin, Isocid, Isocotin, Isokin, Isolyn, Isonex, Isoniazida, Isoniazide, Isonicid, Isonico, Isonicotan, Isonicotinohydrazide, Isonicotinoylhydrazine, Isonicotinsaeure-Hydrazid, Isonicotinylhydrazide, Isonidrin, Isonilex, Isonindon, Isonizide, Isotebezid, Isozide, Isozin, Isozyd, Lafepe, Laniazid, Mayambutol, Mybasan, Neoteben, Neoxin, Neumandin, Nevin, Niadrin, Nicetal, Nicizina, Niconyl, Nicotibina, Nicotisan, Nicozide, Nidaton, Nidrazid, Nikozid, Niplen, Nitadon, Nydrazid, Nyscozid, Pelazid, Pycazide, Pyricidin, Pyridine-3-Carbohydrazide, Pyridine-4-carbohydrazide, Pyrizidin, RU-EF-Tb, Raumanon, Retozide, Rimicid, Rimifon, Rimiphone, Rimitsid, Robisellin, Sauterazid, Solonex, TB-Vis, Tebecid, Teebaconin, Tekazin, Tibinide, Tibizide, Tisin, Tisiodrazida, Tizide, Tubazid, Tubazide, Tubeco, Tubicon, Tubilysin, Tubomel, Tyvid, Unicozyde, Vazadrine, Vederon, Zidafimia, Zinadon, Zonazide, [(4-Pyridinylcarbonyl)oxy]hydrazine, 5015 R.P., Isonicotinic hydrazide, Isonicotinic acid hydrazide, 4-Pyridinecarboxylic acid, hydrazide, FSR 3, Pyridine-4-carboxylic hydrazide

Description

Applications Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

• Brand: TRC

Chemical properties

• Molecular weight: 137.14
• Formula: C₆H₇N₃O
• Color/Form: White To Off-White
• InChI: InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N
• SMILES: NNC(=O)c1ccncc1