1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

CAS: 203911-27-7

Ref. TR-I882200

Product Information

• Name: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
• Synonyms: HA1077, Fasudil Dihydrochloride, HA-1077, Dihydrochloride Salt, Fasudil dihydrochloride hydrate, 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride

Description

Applications A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
References Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),

• Brand: TRC

Chemical properties

• Molecular weight: 364.29056
• Formula: C₁₄H₁₇N₃O₂SHCl
• Color/Form: Neat
• InChI: InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• InChI key: InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N
• SMILES: O=S(=O)(c1cccc2cnccc12)N1CCCNCC1