Product Information
Name:JNJ-7706621
Controlled Product
Synonyms:
- N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine
- 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-yl]amino]benzenesulfonamide
- JNJ 770662
Brand:TRC
Description:Applications JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma.References Matsuhashi, A. et al.: Curr. Cancer Drug Tar., 12, 625 (2012); Emanue,l S. et al.: Cancer Res., 65, 9038 (2005); Seamon, J.A. et al.: Mol. Cancer Ther., 5, 2459 (2006);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:394.356
Formula:C15H12F2N6O3S
Color/Form:Neat
InChI:InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
InChI key:InChIKey=KDKUVYLMPJIGKA-UHFFFAOYSA-N
SMILES:N=c1nc(Nc2ccc(S(N)(=O)=O)cc2)[nH]n1C(=O)c1c(F)cccc1F
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