(-)-a-Kainic Acid

CAS: 487-79-6

Ref. TR-K135010

Product Information

• Name: (-)-a-Kainic Acid
• Synonyms: (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid, 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic Acid, (-)-Kainic Acid, (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic Acid, Digenic Acid, Digenin, Helminal, Kainic Acid, L-a-Kainic Acid, (-)-α-Kainic acid, (2-Carboxy-4-isopropenyl-3-pyrrolidinyl)-essigsaeure anhydrous, (2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid, (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid, (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline, 3-(Carboxymethyl)-4-Prop-1-En-2-Ylproline, 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)-, 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, [2S-(2α,3β,4β)]-, 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-, <span class="text-smallcaps">L</span>-α-Kainic acid, Digenic acid, L-α-Kainic acid

Description

Applications (-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997), Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)’

• Brand: TRC

Chemical properties

• Molecular weight: 213.23
• Formula: C₁₀H₁₅NO₄
• Color/Form: Neat
• InChI: InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1