Product Information
Name:KP372-1
Controlled Product
Synonyms:
- 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one compound with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Brand:TRC
Description:Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:448.36
Formula:C10H4N6O·C10H4N6O
Color/Form:Neat
InChI:InChI=1S/2C10H4N6O/c17-9-6-4-2-1-3-5(6)7-8(9)11-10-12-14-15-16(10)13-7;17-9-6-4-2-1-3-5(6)7-8(9)13-16-10(11-7)12-14-15-16/h2*1-4H
InChI key:InChIKey=CWFOAASSUQIXOW-UHFFFAOYSA-N
SMILES:O=C1c2ccccc2-c2nc3nnnn3nc21.O=C1c2ccccc2-c2nn3nnnc3nc21
Technical inquiry about: KP372-1
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