Product Information
Name:KU-0058948
Controlled Product
Synonyms:
- 1(2H)-Phthalazinone
- 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-
- 1H-1,4-Diazepine
- 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro- (9CI)
- 4-[[4-Fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
- KU 0058958
Brand:TRC
Description:Applications KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitroReferences Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:380.42
Formula:C21H21FN4O2
Color/Form:Neat
InChI:InChI=1S/C21H21FN4O2/c22-18-7-6-14(12-17(18)21(28)26-10-3-8-23-9-11-26)13-19-15-4-1-2-5-16(15)20(27)25-24-19/h1-2,4-7,12,23H,3,8-11,13H2,(H,25,27)
InChI key:InChIKey=HGEPGGJUGUMFHT-UHFFFAOYSA-N
SMILES:O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCCNCC1
Technical inquiry about: KU-0058948
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