Product Information
Name:(+)-Lactacystin
Controlled Product
Synonyms:
- (2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Brand:TRC
Description:Applications A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex).References Fenteany, G., et al.: Science, 268, 726 (1995), Fenteany, G., et al.: Proc. Natl. Acad. Sci. USA, 91, 3358 (1994),
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Chemical properties
Molecular weight:376.43
Formula:C15H24N2O7S
Color/Form:Neat
InChI:InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
InChI key:InChIKey=DAQAKHDKYAWHCG-IDRMDIHUSA-N
SMILES:CC(=O)N[C@@H](CSC(=O)C1([C@H](O)C(C)C)NC(=O)[C@H](C)[C@@H]1O)C(=O)O
Technical inquiry about: (+)-Lactacystin
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