(R)-Laudanosine

CAS: 85-63-2

Ref. TR-L178520

Product Information

• Name: (R)-Laudanosine
• Synonyms: (1R)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline, (R)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline, 1βH-Laudanosine, (-)-Laudanosine, D-(-)-Laudanosine, D-Laudanosine, O-Methyllaudanidine, l-N-Methyltetrahydropapaverine
• Brand: TRC
• Description: Applications (R)-Laudanosine is an isomer of (S)-Laudanosine (L178525), a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Canfell, P., et al.: Drug Metab. Dispos., 14, 703 (1986); Anselmi, E., et al.: J. Pharm. Pharmacol., 44, 337 (1992); Bohrer, H., et al.: Pharmacol. Toxicol., 73, 137 (1993)

Chemical properties

• Molecular weight: 357.44
• Formula: C₂₁H₂₇NO₄
• Color/Form: Neat
• InChI: InChI=1S/C21H27NO4/c1-22-9-8-15-12-20(25-4)21(26-5)13-16(15)17(22)10-14-6-7-18(23-2)19(11-14)24-3/h6-7,11-13,17H,8-10H2,1-5H3/t17-/m1/s1
• InChI key: InChIKey=HWPBPTAOXVIKGI-IYPAPVHQSA-N
• SMILES: CS(=O)(=O)c1ccc([C@H](O)[C@@H](N)CF)cc1.Cl