Ledipasvir-d6

CAS: 2050041-12-6

Ref. TR-L320102

Product Information

• Name: Ledipasvir-d6
• Synonyms: N-​[(1S)​-​1-​[[(6S)​-​6-​[5-​[9,​9-​Difluoro-​7-​[2-​[(1R,​3S,​4S)​-​2-​[(2S)​-​2-​[(methoxycarbonyl)​amino]​-​3-​methyl-​1-​oxobutyl]​-​2-​azabicyclo[2.2.1]​hept-​3-​yl]​-​1H-​benzimidazol-​6-​yl]​-​9H-​fluoren-​2-​yl]​-​1H-​imidazol-​2-​yl]​-​5-​azaspiro[2.4]​hept-​5-​yl]​carbonyl]​-​2-​methylpropyl]​-​carbamic Acid Methyl Ester-d6
• Brand: TRC
• Description: Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Chemical properties

• Molecular weight: 895.04
• Formula: C₄₉H₄₈D₆F₂N₈O₆
• Color/Form: Neat
• InChI: InChI=1S/C49H54F2N8O6/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50,51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6/h8-10,12-14,18-20,22,24-25,29-30,38-41H,7,11,15-17,21,23H2,1-6H3,(H,52,55)(H,53,54)(H,56,62)(H,57,63)/t29-,30+,38-,39-,40-,41-/m0/s1/i5D3,6D3
• InChI key: InChIKey=IGMNYECMUMZDDF-UHFFFAOYSA-N
• SMILES: O=C(O)Cc1cc(O)ccc1O