Estimated delivery in United States, on Tuesday 28 May 2024
Product Information
Name:
LEE011 Succinate
Controlled Product
Synonyms:
- Butanedioic acid
- compd. with 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1)
- LEE 011BBA
- NVP-LEE 011
- Ribociclib succinate
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
- 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Succinate
- Ribociclib Succinate
CAS:
Description:
Applications LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
References Kim, S., et al.: Mol. Cancer Ther., 12, PR02 (2013); Rader, J., et al.: Clin. Cancer Res., 19, 6173 (2013)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
552.63
Formula:
C27H36N8O5
Color/Form:
Pale Beige Solid
InChI:
InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)
InChI key:
InChIKey=NHANOMFABJQAAH-UHFFFAOYSA-N
SMILES:
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1.O=C(O)CCC(=O)O
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-L321000 LEE011 Succinate
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